This is a clip from the Oprah show. Randy Pausch gave this lecture at his university in September. He at the time was given 3-6 months to live.
The talk this gentleman gave was very inspiring seeing especially knowing his recent news. What I thought sad about this talk watched by literally millions of people (over 6 million hits on the Internet to date) was that he gives credit to 'karma' and following your dreams to live a successful life. He talks of great principals; people over things, choose not to complain, choose to be happy, etc. all which are great. I think it is sad that for him, he sees the end of this life the end.